I don't think ClojureScript could become popular beyond a subset of Clojure users unless it becomes self-hosted, so it can be compiled without a JVM and eval in a browser with an extension. The JVM is not universally loved/acceptable.
I keep meaning to make a game with it, but always give up because it's so much more painful than pretty much any other to-JS language.
That might be, but it's young yet. Just seeing its ideas (or general functional programming in general) getting more widespread, like React here, feels good to me. I have more pain points with JS. I'd rather deal with build difficulties than have to handle DOM state, evented programming and JS quirks.
I keep meaning to make a game with it, but always give up because it's so much more painful than pretty much any other to-JS language.