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The authors have uploaded a copy of the paper which can be accessed here: http://hsci.harvard.edu/files/hsci/files/pagliuca_et_al_cell...

(I'd actually recommend giving the paper a skim even if you're not trained in biology. The Introduction and Discussion should still be very comprehensible, and while the Results do suffer from the alphabet soup problem (as do most biological papers), the overall structure of the evidence should be clear - pay particularly close attention to Figure 5A and Figure 6A-C).

Commentary from a very well regarded stem cell scientist (and prolific blogger, Paul Knoepfler) here: http://www.ipscell.com/2014/10/top-10-takeaways-from-harvard...

The key next challenge appears to be the creation and testing of appropriate delivery device that can enable persistent survival of the differentiated cells while still enabling them to sense blood glucose levels.



The paper was fantastic! The discussion section is a must-read for seeing where this is going.

The calcium ion flux response to glucose challenge was neat. Demonstrates the signaling mechanics being as expected.




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