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Some yes.

Kidney failure in a small set of patients. Typically urine/blood samples are taken for the first few months to check for this. There's some evidence of bone degradation in long term use (think 10+ years) but its mitigated with regular strength exercises. Beyond that not much else the formula has been altered a few times to make it pretty safe to take regularly.

Some people experience gastrointestinal distress from it but that usually passes after a month. If it doesn't they usually just stop taking it.

All of the side effects stop if you stop taking it.



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