I think Datomic is a very interesting project for a variety of reasons like use of Datalog, immutability etc.
This particular thing seems like a backwards step though. One of the major reasons why relational databases became so popular was that: the user didn't have to think about which predicate to put first in the where clause, or which join to do first. Query optimizers can do that much better, and there is decades of research on how to optimizer relational queries (including Datalog queries -- see Deductive Databases). It is hard for users to make such decisions, and complex queries, views, runtime parameters make it near impossible to reason about performance of different queries.
One thing to remember in high write environments: if you're storing a uuid attribute and it's indexed, use datomics squuid (sequential uuid). Rewriting the indexes will go MUCH faster and prevent latency spikes on queries.
The "put your most restrictive clauses first" rule (which is reiterated on the new Best Practices page) usually seems to do the trick in our hands.