I tried reading your post with an open mind, but starting with your first citation of PMID 38753870 you neglect to mention it was a study done in genetically modified mice. For you to claim it is "the single most powerful supplement for lowering its risk might be urolithin-A" right after you confidently assert "Beta-amyloid is a symptom of AD, not the cause" looks like you're just as bad at jumping to conclusions as the beta-amyloiders you "don't know how could mix this up."

In effect I asserted that neuroinflammation is at the root of AD, and that factors that lower it will in turn lower the risk of AD. This I stand by completely, and so the lifestyle factors that lower neuroinflammation are relevant. As for PMID 38753870, it is just one of many relevant studies showing brain health benefits from urolithin A. In particular, urolithin A works by inducing mitophagy (among its many other effects), with mitophagy improving mitochondrial health and therefore metabolic health. Unhealthy lifestyle choices compromise the excitatory/inhibitory balance in the brain, and it goes downhill from there.

What we have today in the field of drug development, and we have had this for many years now, is the development of cost-inefficient late-stage treatments that maximize revenue exploitation, but often don't even work. Instead, what we need is early-stage and preventative diagnostic measures, and cheap scalable generic small molecules or vaccines, coupled with lifestyle and environmental changes, that together reverse or treat the condition when it's still reversible or treatable. We will not get this from the FDA because it's 100% in bed with the scientific mercenaries that like to call themselves scientists. Moreover, I assert that most of the ones downvoting my comments here represent the mercenaries that work in the industry to earn some of this exploitative revenue for themselves, and they don't want the size of the pie to be reduced.