I’m more than happy to let the rich buy the best genes first, if that means that everyone else will get to buy them later.
Is the implied attitude that if the rich get something first it shouldn’t exist at all? If gene therapy follows a progression like mobile phones, that would good for humanity. First it’s super expensive and only a few get them, but it becomes much cheaper within a few decades and eventually almost everyone can have one.
>I’m more than happy to let the rich buy the best genes first, if that means that everyone else will get to buy them later.
Why would they sell it to you later?
Even more so, why would they even need most people (say 80% or so)? Automation wins and AI means they don't have to, in order to maintain their status quo and build things.
It's more likely for the west to become the same way large parts of the third world already are: some highly advanced zones cut off by walls, police, private armies etc. (which get the genes) and huge areas of slums...
For the same reason they sell mobile phones. Because the marginal cost is much lower than what they sell it for.
The "rich" aren't a single person. If Jeff Bezos refuses to sell you something, Tim Cook will see an opportunity to take the market from under him. Competition is why they'll sell it to you.
If you don't believe this, can you give examples of cases where "the rich" have successfully withheld a beneficial technology from everyone for more than a few decades?
> Even more so, why would they even need most people (say 80% or so)?
This is going into highly speculative territory. All I can say is if you think this is the future then you should be hoping and praying that genetic research advances faster than AI does.
If AI can eliminate 80% of the workforce, it's only a matter of time before it eliminates 100%, at which point "rich" doesn't matter anymore as that's a human distinction only. In an AI dominated future isn't genetic research even more critical because it's one of the few outs for human beings to remain economically relevant?
AI is a means of production. Unless you talk about the sentient, human level kind that managed to become uncontrollable.
All that new technology will accelerate wealth inequality. Markets follow wealth, thus the future R&D, tech & manufacturing will focus less on the median citizen. The danger is this being a positive feedback loop (aka self reinforcing, speeding up towards infinity instead of finding a stable equilibrium). Yes, those system might have always existed, but so far have accelerated slow enough to not become a big problem for us.
Those drastic increases of wealth inequality will come with drastic centralization of power, even in our democracies. The few on top will be less and less dependent on many of their fellow citizens. I don't see this ending in a utopian society, unless there is a miracle making those "good", altruistic individuals. But if we learned anything in the past, then it is that political / power system never work long term if they require a "good" king.
> Unless you talk about the sentient, human level kind that managed to become uncontrollable
The poster I responded to claims 80% human job elimination by AI. That implied AI that is better than human for the vast majority of jobs. We’re well past the threshold for Westworld style general AI if we get even close to endangering 80% of human jobs.
I’m skeptical. Do you have an argument to back up that claim? Doctors and nurses that provide direct healthcare are more than 1% of workers, are you saying AGI that replaces a doctor can’t be considered “strong AI”?
A doctor performs a well defined task: he collects data about a patient as inputs to his mental model, and produces diagnosis as the output (and selects a treatment based on established guidelines for the diagnosis, and relevant patient characteristics). I don't see anything in this process that requires AGI. In fact I think a doctor is one of the easier professions to automate, and it will probably be automated relatively soon.
Nurses which provide emotional support to patients might be harder to replace with AI, but that too will change as AI starts to become more and more "human-like" (i.e. more complex), but not necessarily AGI level.
Speaking as someone who works in the space, this is wildly optimistic. All I can say is your view of AI is pretty off. You need pretty fantastic AI just to understand what a patient is telling a doctor, let alone make a diagnosis.
Looking at national stats for medical errors, and given how bad most doctors I interacted with are at listening, and making diagnosis, I'd say the bar for AI is set pretty low.
>>> If you don't believe this, can you give examples of cases where "the rich" have successfully withheld a beneficial technology from everyone for more than a few decades?
But its not like the "rich" could let the "not rich" have that beneficial technology because once you have that technology you become "rich". So it's a meaningless example.
>For the same reason they sell mobile phones. Because the marginal cost is much lower than what they sell it for. (...) The "rich" aren't a single person. If Jeff Bezos refuses to sell you something, Tim Cook will see an opportunity to take the market from under him. Competition is why they'll sell it to you.
There's no need for Bezos and Cook to sell you anything if you don't have any money -- and there's no reason for you to have money if they don't need your services.
They will either pay you some UBI to keep you from storming their 10%-20% secluded parts of the city, or just use private armies for that and leave you to rot...
>If AI can eliminate 80% of the workforce, it's only a matter of time before it eliminates 100%, at which point "rich" doesn't matter anymore as that's a human distinction only.
If you have the guns, the state, and the money, then it doesn't matter whether rich "matters anymore", you can use your power to keep them...
Because the rich are no more evil than the rest of us and, all things being equal, would rather their fellow man be as happy, healthy and fulfilled as they are?
A good portion of HN readers are rich. If you take the perspective of an average 3rd world laborer, vast majority of HN readers are rich, likely including you. Maybe we're more evil than average, but I have to admit, I haven't noticed.
Humans are communal creatures who have particularist ties to people in their own society. If we want to speak about the intentional beliefs of the rich, I think we need to take an intra-societal view rather than a cosmopolitan one.
Five reasons why the rich tend to be worse people:
1) Humans only need some modest necessities to live and a stable income to be secure, and beyond this, our desires are largely manufactured and driven by status
2) Unlike in the past, today, the higher our income the longer hours we are likely to work
3) There are many people who are poor and destitute and need money orders of magnitude more than the rich
4) People have a tendency to search for legitimations for their actions, and so the rich try and justify their wealth as a result of merit, natural inequality, work ethic, etc.
The rich are disproportionately driven by status, spend less time with their friends and family - and indeed their lives are absorbed in instrumental gain - hoard wealth at the grave expense of others, and are given to excessive pride and covetousness.
You might be right, in the sense that all humans possess the capability to be greedy and inflict harm on others for their own gain - it's just the rich who are in more of a position to execute on those desires.
How would the rich prevent the rest of us from getting the same treatment? In theory it's possible if they keep the technology a secret, but these are very difficult to protect (especially in California where non-compete clauses are unenforceable). Patents are much easier to enforce but they expire after a couple of decades.
Because the more people live in the universe the richer everyone of them is. Rich person who owns the whole planet all by himself is much poorer than anyone of us because he can't buy a phone watch a movie or learn new science.
Of course things change a bit If AI can do all of this thisgs, but then AI are the new people, and instead of rich vs poor rich would worry about AI vs people.
Why wouldn't they? This is the way everything has worked: A company comes up with a procedure, it's expensive because of R&D, then it becomes cheap so everyone can afford it. Why would this be any different?
cynic in me thinks that there's no golden rule and that yeah .. unless they enjoy profits by selling it to you, you won't see a shadow of therapy until 200 years when they settled their advantage so much their only remaining game is making you hope for a little better life.
The dangers are clear, we haven’t discovered all the correlations between various genes and how they express themselves. Biggest risk is a neurodegenerative condition that takes thirty years to show.
Wouldn't it make more sense to compare the likely progression with standard drug development rather than mobile phones?
Last I checked, drug development is in a terrible state. I mean we're killing 70k+ people a year from opiate overdoses that were primarily driven by our capitalist drug development system (and a lack of even an ounce of morality at some of these companies). And that's just one problem among many. Not everything is the tech industry.
What do opiate overdoses have to do with the state of drug discovery? Aren't opiate analgesics like an infinitesimal blip compared to the broader pharma market?
That “evil capitalist drug development system” that turned AIDS from a death sentence into a chronic illness, using anti-retrovirals some of which are already becoming generics?
Humanity is the blink of an eye in the universe. Claiming the suffering is always worth it (ie doesn't matter), is defeatist. Not sure how that's an argument for how dissemination of medical tech is "working".
this whole article is hilarious. biology and genetic engineering is way way more complicated than anything we’ve done as far as software and hardware goes. performing a few tricks does not equal we can enhance anything we want any way we want it. my guess is that we’re a few decades away from really understanding the underlying mechanisms that would allow us to truly enhance ourselves. some will say that we can edit DNA today - while that’s true we have a limited understanding of what we’re doing or what the effects might be. Evolution is great because it wipes out all of its errors and you only see the beautiful end product. Now, do you want to be a guinea pig and/or be the unfortunate outcome of these experiments?
another point that a lot of people miss is that super intelligence means nothing if you don’t have the right environment and the right opportunities. being wealthy exponentially increases your chances of a good outcome and it’s almost orthogonal to your IQ.
yet another point is that if we continue to destroy our ecosystem no matter how smart individuals get we’re all collectively doomed.
I can pretty confidently say that we will never fully understand human cell biology/biochemistry. The interplay between proteins, genes, metabolites, etc is mindbogglingly complex. I say this as someone who works as a chemical biologist and uses CRISPR/Cas9 in my work to perform gene editing in cancer cells.
We are still quite a ways away from performing real editing in humans, and even then it's gonna be a crapshoot. Most traits are polygenic, and we don't understand how tweaking one gene will effect distal biology.
Yeah, what people miss is that nano-machines have been stalled for a while despite being a clearly simpler problem than repurposing biological life. Silicon based computation really lots like extraordinary and particular situation which allowed humans exploit miniaturization fantastically. And people have been aiming to duplicate this success in other fields futilely for many years now.
Editing DNA is far, far away from creating chips, which a ways from writing software. It's very likely well in the realm of "AI-complete problems".
The tourism angle mentioned is the real deal killer for these regulations.
If you outlaw this, people like me (who think inflicting stupidly and ill-health on their children by withholding these technologies is morally wrong) will just fly to Singapore. Even if you could enforce this, not every country will. 5+ standard deviation increases in many traits is on the table: https://www.gwern.net/Embryo-selection#iterated-embryo-selec...
If we make this illegal here, we will be as children compared to those in China or Singapore.
The potential increase in IQ is so high that any country that defects from a global ban, even a smallish one like Iran say, would quickly be producing the vast majority of all genius-level intellects.
A global ban is just is not a stable equilibrium.
From a balance-of-power perspective, we would expect huge shifts in future power to those countries that embrace the technology. An absence of taboos against human enhancement may be a more important factor in this than current scientific achievement for predicting global leadership in the next couple generations.
In islamic culture, traditional scholarship places the point of ensoulment anywhere between 40 and 120 days after conception. Our western taboos around this topic, likely even our western secular taboos, derive from a belief in ensoulment at conception.
This simple doctrinal dispute may end up having huge consequences. And may allow islamic cultures to return to a position of scientific power, likely shared with China and other Asian countries who similarly do not share our taboos.
I think you're placing far too much faith in genetic determinism. Intelligence is a highly fluid concept with no widely accepted defining characteristics. To think that geneticists can just "pick and choose" genes to add to an embryo that will reliably result in genius level intellects is absurd. The human mind is not a tomato plant or a wheat kernel. It's a highly complex system that requires a multitude of biological and environmental factors to flourish into an above average intelligence.
"I am, somehow, less interested in the weight and convolutions of Einstein’s brain than in the near certainty that people of equal talent have lived and died in cotton fields and sweatshops."
That is Stephen Jay Gould and I just reread the Mismeasure of Man, an excellent inoculation against essentialist beliefs about the incarnation of intelligence.
I am afraid Paul Krugman's take on Gould is pretty accurate:
"Now it is not very hard to find out, if you spend a little while reading in evolution, that Gould is the John Kenneth Galbraith of his subject. That is, he is a wonderful writer who is bevolved by literary intellectuals and lionized by the media because he does not use algebra or difficult jargon. Unfortunately, it appears that he avoids these sins not because he has transcended his colleagues but because he does does not seem to understand what they have to say; and his own descriptions of what the field is about - not just the answers, but even the questions - are consistently misleading."
I do find it amusing how people who claim intelligence is 100% environment are also terrified of letting others select for intelligence. It is almost like they know, deep down, that it will work. That intelligence, like almost every other trait we have measured, has a very large heritable component: https://en.wikipedia.org/wiki/Heritability_of_IQ
I'm not sure I would put much stock in an economist's assessment of a geneticist. Brilliant people have a terrible habit of assuming that their brilliance in one area implies an elevated ability in other disparate fields as well. Criticism of Gould among biologists is rare and far between from what I've seen.
>"That intelligence, like almost every other trait we have measured, has a very large heritable component"
The problem is what do you mean when you say "intelligence". We can easily measure physical traits like height, weight, strength, etc. But intelligence is practically impossible to measure and define in any meaningful way. IQ tests have been thoroughly debunked as highly dependent on cultural biases and assumptions of learned knowledge. There is no one single measure you can look at and determine the intelligence of an individual which could possibly be predicted by genetics alone.
Gould was a paleontologist, not a geneticist. Gould's reputation is zero in evolutionary biology, an industrious fool.
See this letter to the editor if you want to see what the giants of evolutionary biology thought of Gould:
John Maynard Smith, one of the world's leading evolutionary biologists, recently summarized in the NYRB the sharply conflicting assessments of Stephen Jay Gould: "Because of the excellence of his essays, he has come to be seen by non-biologists as the preeminent evolutionary theorist. In contrast, the evolutionary biologists with whom I have discussed his work tend to see him as a man whose ideas are so confused as to be hardly worth bothering with, but as one who should not be publicly criticized because he is at least on our side against the creationists." (NYRB, Nov. 30th 1995, p. 46). No one can take any pleasure in the evident pain Gould is experiencing now that his actual standing within the community of professional evolutionary biologists is finally becoming more widely known. If what was a stake was solely one man's self-regard, common decency would preclude comment.
But as Maynard Smith points out, more is at stake. Gould "is giving non-biologists a largely false picture of the state of evolutionary theory" -- or as Ernst Mayr says of Gould and his small group of allies -- they "quite conspicuously misrepresent the views of [biology's] leading spokesmen."[1] Indeed, although Gould characterizes his critics as "anonymous" and "a tiny coterie," nearly every major evolutionary biologist of our era has weighed in in a vain attempt to correct the tangle of confusions that the higher profile Gould has inundated the intellectual world with.[2] The point is not that Gould is the object of some criticism -- so properly are we all -- it is that his reputation as a credible and balanced authority about evolutionary biology is non-existent among those who are in a professional position to know: http://cogweb.ucla.edu/Debate/CEP_Gould.html
>IQ tests have been thoroughly debunked as highly dependent on cultural biases and assumptions of learned knowledge.predicted by genetics alone.
If you are interested in the truth, I ask you to approach this subject bloodlessly, as you would a programming problem. Read the book I linked to. Then re-read Measure of Man, if you must.
But before you do, allow yourself to consider that bio-determinism is allowed to be true. There is no god or law of physics that prevents this from being the case. Imagine that these were just brute facts. If they were, your actions may change but your normative commitments do not have to.
I think if you read the literature neutrally, you will find g-factor is basically coherent and well-motivated, and intelligence is heritable. But when reading on matters touched by ideology, I think it is important to allow yourself to believe you can be persuaded.
Let's say we lived in the centuries old, long debunked eugenicist's fantasy you think is reality.
We'd sooner use gene editing to make people more empathetic, briefer in their words, less absolutist, less looking at things as "programmer problems," less engineery. Higher "EQ."
Goulds argument is that different cases have different causes. The difference between my brain and a chimp is mostly genetic. The difference between brains in the neighborhood I grew up in and the brwins in a more wretched to2n are mostly environmental. The act of measuring heriditability without the context for what effect you are analysing is as meaningless as reporting means without variances. Have youbactually read this work? It is primarily a guide to avoiding conceptual phallacies that preceed the experiments/numerical analysis.
I haven’t read Gould, but from what you describe- the people running the studies aren’t dumb, they’re aware of these difficulties! That’s why they use all sorts of means (statistical control, twin studies, etc etc) to get around them, in addition to using compilations of studies from different populations and methods to drive conclusions.
That would be an experimental error. Conceptual error means they take experiments that show that within a homogeneous population, the variances in intelligence (begging the question of "are there multiple types of mind skills which are heriditable?") are 50% or whatever explained by genetics. Then they apply these to explain variances between groups, e.g. US African-Americans compared to US European-Americans.
The fallacy is made clear if you look at something less charged like hight. Clearly, in your town, height variance is mostly due to genetics. However, in genetically similar groups over time, heights have been gradually increasing over the generations. This increase is not because heights are being genetically selected for but because the genome codes for an organism that can grow taller or shorter in different conditions, and these places (e.g. Europe) are providing the "grow tall" conditions. Places that aren't providing these conditions are not seeing their children grow them taller.
Now, height is a lot easier to measure than intelligence, and a lot less politically weighted by the various movements to promote racial inequality. But the conceptual fallacy is the same.
Note that Gould is explicitly attacking a "races are genetically different in some substantive intelligence fashion" movement of his time, using the oddly similar movements from prior times. This eugenics thru biotech argument is not currently racially motivated, but western cultures have suffered thru a number of "eugenics by positive means -> eugenics by racism" shifts in the near past, so we are a bit twichty about it.
tldr: No studies about individual variation will tell you about between non-random subgroup variation.
>This increase is not because heights are being genetically selected for
Can you explain how you know this? Taller people, in general, are often considered more desirable mates. Wouldn't this lead to such people having more children which would lead to, well, average increases in height?
Not OP, but the reference was clearly to increases in height during very short time frames from a natural selection point of view, eg in post WWII Europe.
Krugman’s own thinking about economics (and the role of public intellectuals) has changed a lot since 1996. I am curious if he still feels that way about Galbraith.
That would happen if you cloned one person a million times, but with all the tradeoffs of genetics I doubt there even is a single conclusion to be reached
And yet IQ (which is a pretty good proxy for intelligence) is a highly inheritable trait, as shown by several twin studies.
It is a fact that I had a hard time accepting, considering that it flies in the face of my beliefs about merit, hard work and the importance of education. These things are important, but genes play a huge role too.
It’s well understood that complex traits are polygenic (no single gene or sets of causal variants) but quite easy to predict such traits when looking at the full genome (I agree the resolution of prediction is still not there — but we are in the infancy of this field).
EDIT: Why height is relevant : "Why study height? Height is the “poster child” of complex genetic traits, meaning it is influenced by multiple genetic variants working together. It’s easy to measure, so makes a relatively simple model for understanding traits produced by not one gene, but many."
This is a belief just like God making man and animals on separate days.
We have DNA and (partly) heritable traits just like tomatos and wheat. The only reason modification (eg CRISPR) was done later in humans vs other organisms was due to ethical not technical reasons.
We have easily obtained metrics that work as a proxy for intelligence like IQ, educational attainment, elite professional success, number of patents, publications etc.
As for having many genes being responsible for a trait, Fisher showed in 1918 you can perform selection even if there were an infinite number of loci involved, see https://en.m.wikipedia.org/wiki/Infinitesimal_model
They correlate and as I said are 'easily measured.. proxies for intelligence'
You can't just sequence people who have accomplished great things and are widely recognised as geniuses as there aren't enough of then and they're busy.
We need huge sample sizes. Ideally, you'd sequence a million people and have them sit rigorous tests, interviews etc. But it's way cheaper and faster to have them tick boxes on forms.
>> They correlate and as I said are 'easily measured.. proxies for intelligence'
You're going to have to provide meaningful evidence to back up the assertion that numbers of patents (as well as the other criteria listed) actually correlate to higher intelligence.
There are ethical reasons - of course, but we should also consider safety; which will be a tough one for CRISPR for heritable conditions. What if a modification goes sour in the second generation? What if it leads to mid life cancer? It might be a long time before we know if this is genuinely safe.
You're only mentioning our CURRENT adolescence in this field. Dozens of genes associated with intelligence have already been identified and hereditary studies have already shown intelligence's genetic roots. A geneticist today can no more just "pick and choose" to enhance the intellect of an embryo anymore than Isaac Newton could have just manually entangled two photons, or Alan Turing could have fit something over a billion times more powerful than one of his Bombe machines into a sleek gadget the size of a wallet (with also remote telephony and photographic capabilities!).
This is how science works, humanity learns more and progresses. Just because something is complex to you today doesn't mean it will still be complex to you 50 years from now.
There was a good meta analysis of the impact IQ has on outcomes estimating that, while statistically significant, IQ was not much better of a predictor of success than parent’s socioeconomic status or education, and high IQ people still have a wide variance in outcomes. So while you may get a bump, achieving Gattica-style world domination through gene editing seems a little far fetched.
Despite the
modest conclusion, these results are important because
they falsify a claim often made by the critics of the
“testing movement”: that the positive relationship
between intelligence and success is just the effect of
parental SES or academic performance influencing
them both (see Bowles & Gintis, 1976; Fischer et al.,
1996; McClelland, 1973). If the correlation between
intelligence and success was a mere byproduct of the
causal effect of parental SES or academic performance, then parental SES and academic performance
should have outcompeted intelligence as predictors of
success; but this was clearly not so. These results
confirm that intelligence is an independent causal
force among the determinants of success; in other
words, the fact that intelligent people are successful is
not completely explainable by the fact that intelligent
people have wealthy parents and are doing better at
school.
In other words, there are two models:
1) Your parents being rich makes you rich and also makes you good at IQ tests.
2) Heritable intelligence makes you rich and also made your parents rich.
The article says the first model is falsified in favor of the second. That's pretty much the opposite of what you say in your comment.
For 2 I could imagine that intelligence makes you rich - and if heritable wealth would run in the family. But be clear, other factors are much more important in getting rich - aggression, ruthlessness, a lack of imagination.. and being positive; a strong family affinity, luck, hardwork, attention to detail. The ability to reason and learn is clearly very useful, but it's not exclusively useful in our society, and in the not very distant past it was not very useful at all to the vast majority of economic actors. For example - if you are a land owner in a preindustrial society the opportunities for scheming and thinking are far more limited than if you are a startup owner in the modern day.
You don't seem to understand that part of the article.
There are no discrete models for inheriting intelligence and wealth, and making such sweeping claims about this issue is just not warranted.
It has been shown that wealth improves children's intelligence and "success". It has also been shown that intelligence is one factor in success, but not the only one. Even academic success is "only" about 70% dependent on IQ.
Another problem is the difference in backgrounds for such studies among different countries. Sometimes wealth will have a big impact on childhood health (for example developing countries) and sometimes it doesn't (developed nations with proper medical systems, i.e. every one except US).
Socioeconomic status (SES) _is_ primarily your family's money. Where it comes from might easily include your family's genetics, e.g. genetics for intelligence. The parent's point, I think, was that controlling for SES in studies of the effect of intelligence on outcomes is likely to be a mistake, because SES itself will be caused by parental intelligence, which correlates with own intelligence via genetic (and other) pathways.
I'm very tired of people demanding that I believe obvious nonsense like this claim that differences in skill don't exist or that differences in skill don't affect material outcomes. I get that you don't like meritocracy, but I'm not going to accept claims that it's some kind of myth. Hard work and talent leads to success.
"over 60 percent of the Forbes richest 400 Americans grew up in substantial privilege" (wikipedia) and add in race and gender rigging of the system and IQ is a factor among others.
Wealth can only accumulate exponentially, and there are big limitations for the "growth" factor. You have to build on the wealth of your parents. This makes it substantially easier for those with richer parents!
> The potential increase in IQ is so high that any country that defects from a global ban, even a smallish one like Iran say, would quickly be producing the vast majority of all genius-level intellects.
I do not know if this is even true. But, I do not see the USA rushing to give good education to its population. The geniuses are already there in crowded classrooms and underfunded schools.
And, a good education pays off even for less gifted people. Their lives are better, they contribute more to the economy and less to crime.
If that race is one, the USA (and Europe also) are already trailing.
Education is more a filtering mechanism than an enrichment mechanism. Panning does not create gold.
Regardless, 5 standard deviations is enormously huge. Every person born would be as smart as the most elite scientists today. The most elite scientists in the future will be far smarter than anyone who ever lived.
This has enormous military consequences, much larger than squeezing the dry rag of education.
>Education is more a filtering mechanism than an enrichment mechanism. Panning does not create gold
This is a pretty bad analogy man. Education, starting with basic literacy & numeracy, improves virtually everyone who goes through it- which is why mandatory education is part of every society now. Literacy alone completely changes outcomes for say women in developing countries. Just mandating an extra 4 years of high school in agricultural countries that really could've used the teenage help in the fields was a huge step forward for humanity. Education is an improvement process more than a filtering process, no one is born knowing how to read, count, do algebra, code, etc. I agree it does contain a filtering element too, but societies where the construction workers & janitors can read are better than ones where they can't
Not who you responded to, but as someone who spent many years in education I find Caplan's case deeply unconvincing. Yes, education has a component of signaling, but he assigns far too much value to it.
I find the core of his argument rests on the assertion that we all went through school and don't think we learned much of value/it didn't help us. What he's actually describing here is a form of the curse of expertise. Humans are incredibly bad at remembering what it was like to not know things, it's why people make such atrocious teachers without training. But educators are actually helping to build valuable skills and complex mental models that would not arise naturally.
If you interact with homeschooled children of deeply incompetent parents or certain alternative schooling systems (Scientology schools mess their kids up) you can see what the alternative provides, and it's not pretty.
As somebody who spent many years in education (as a student and about 1 year as a teacher) I find Caplan's case deeply convincing.
Caplan actually goes through reams of evidence. As an extreme example, in 2008-9 there were 34000 new history graduates in the US. But there are only 3500 historians working in the whole country.
Now, are you trying to argue that history can actually measurably improve productivity in other fields, such as accounting, and it's just the curse of knowledge that prevents us from seeing this?
Also, incompetent homeschooling parents and Scientology schools are hardly the only alternatives to public schooling. One option that Caplan advocates strongly is vocational training. Instead of giving them history classes, let teenagers who chose to do so become apprentice carpenters, there are 900000 of those.
You're straw-manning here, Caplan makes a broad argument against public education at the primary, secondary, and post-secondary levels, I said I disagree with his large scale conclusion and you're asking me to defend the number of history degrees in the US.
The US public school system is in need of wide reforms at all levels, I'm not going to defend it piecemeal because there are many pieces that are not defensible. None of that makes Caplan right though.
Regarding the first point, Caplan personally estimates that about 80% of education is signalling and that 30% is the lowest figure one can plausibly maintain.
As for the second point, I wouldn't bet my life on it. But I think the case is strong enough that experimental measures in that direction are warranted.
Do you have a more on point summary? That's a lot of text and the parts I skimmed say little against education. Obviously education is used for signaling ability. Not using it this way would be stupid, since it's one of the best tools for that we have. Kind of like the SSN seems to be used as ID in the US. Doesn't mean both of them don't also serve their original purpose anymore. And I haven't found much of of that in that 11 page blog post.
Then there is a bunch about how to build better schools. This seems reasonable in principle, since the way we teach especially in early years is still heavily influenced from by long ago times with different workforce needs and a different culture in general. But lets better not get into the actually mentioned proposals. And this still does hardly fit the "IQ unrelated from schools" narrative discussed in the comments here.
So back to those: If school has no impact, then were do those traits we aspire come from? Are here actually people who believe you can just dump an infant with perfect genes in front of a TV, feed (&co) it regularly, and then expect it to become a genius in adulthood? If not, then what makes the difference and why shouldn't some "school" help citizens apply whatever it is, supported by policy?
In brief: there are strong reasons to believe that much of higher education and even large parts of school serve not to teach but to test students. An English major doesn't lead to higher pay because it makes one a substantially better worker. It does so because achieving it signals three primary traits to the potential employer: intelligence, conscientiousness, and conformity.
This isn't education's only function. Some learning undeniably still takes place. But in Caplan's estimation signalling is probably about 80% of the payoff.
This picture is supported by a large number of observations:
- Why do even top schools like Harvard make little to no effort to prevent non-students from attending lectures?
- Why do students cheer when class is canceled?
- Why does ratemyprofessor.com have the measures "overall quality" and "difficulty" but not an explicit "informativeness" measure and why is high difficulty considered bad?
- Why do students cheat on tests and why do teachers make such a large effort to prevent it?
- Why do employers rarely show concern that you might've forgotten what you learned?
- Why do statistics indicate that graduation year has a much greater effect on wages than all the other years?
All these points contradict the "education = learning" viewpoint but are straightforwardly explained with the signalling model.
And once you acknowledge the importance of signalling it puts statements such as
> And, a good education pays off even for less gifted people. Their lives are better, they contribute more to the economy and less to crime.
into a completely new perspective. As Caplan writes:
> The classic example: You want a better view at a concert. What can you do? Stand up. Individually, standing works. What happens, though, if everyone copies you? Can everyone see better by standing? No way. Popular support for education subsidies rests on the same fallacy. The
person who gets more education, gets a better job. It works; you see it plainly. Yet it does not follow that if everyone gets more education, everyone gets a better job. In the signaling model, subsidizing everyone’s schooling to improve our jobs is like urging everyone to stand up at a concert to improve our views. Both are “smart for one, dumb for all.”
> In the signaling model, subsidizing everyone’s schooling to improve our jobs is like urging everyone to stand up at a concert to improve our views.
It seems that model doesn't even attempt to pretend anymore that our society gives equal opportunity to everyone? Now only the rich shall have the opportunity to signal? That's why I didn't want to go into the actual proposals in that critique... at best they seem to ignore all the complexity of the actual world we live in. Kinda reminded me of someone who just discovered Libertarianism and now thinks governments are totally unnecessary.
If his argument would be "we should reduce signaling", I'd totally love for that to be possible. But I'm not sure it actually is, when taking all the game-theoretic aspects of the real world into account. Maybe all he wants is to reset the out of control spiral of signaling for now? But if the only way we can do so is also a 0.1%er-capitalists wet dream, then I've little hope for the future. Signaling will always exist and be necessary as long as there is a competitive job market, and I don't see society working without.
Anyway, thanks for taking the time to respond. I like the first observation, since it highlights how narrow the allowed path for effective signaling is. Just finishing the material isn't enough, you have to be accepted into the school through official ways. Some observations are kind of weak, though. Especially the second, since it boils down to many people preferring short term gratification over long term success. Students will cheer even if tests are standardized and those canceled classes thus will lead to worse grades => failure at signaling.
....all education? Basic literacy & numeracy? Teaching children how to count and their ABCs? How do you think civilization would function, then? I think that Caplan is arguing against college and further on
'Genetic engineering' routinely moves traits by 5 standard deviations. Countless breeding programs have accomplished that or much more, and even under the narrowest definition of 'genetic engineering', something like editing in chestnut blight resistance will increase the trait by many SDs (going from ~0% chestnut trees surviving to a large fraction of them surviving). That is, after all, how evolution works.
No, complex traits too. Come on. Dog intelligence and personalities? The domesticated foxes? Any of the many mouse/rat selective breeding experiments like Tryon? Personality, intelligence, these sorts of traits are all highly heritable and about the only thing everyone can agree on that heritability means is that you can select on it. 'virtually unlimited interactions between genes and environmental factors'? Give me a break!
> Add in the serious consequences of mistakes. The limited supply of subjects. The difficulty of grading the success of any modification.
??? None of that is a real problem. You are wildly gesturing at hypotheticals and making stuff up. Being 'polygenetic' is not a problem, it's a blessing.
> For intelligence, we don't even know what kinds of changes we would want to make, even if we could make them reliably.
Yes, we do. The PGSes have identified hundreds of variants at genome-wide significance, and there are thousands at high posterior probability, with nontrivial cumulative predictive power in the general population.
You don't understand the science behind animal breeding, or quantitative genetics and I assume that is why you think you can do the same to Humans.
The number of subjects absolutely does matter. Selecting mice for intelligence is all nice and well, but you have to breed thousands, and "discard" most of them. Both in traditional breeding as well as with genetic engineering, you have to have sufficient number of trials to conclude anything.
With Human subjects, given ethical and practical constraints (lifespan), that's going to be a lot tougher.
You can reliably quantify the intelligence of a mouse at a few weeks of age and breed it soon thereafter (though you would probably use that "IQ" to score its parents). You can't reliably quantify health and intelligence of a Human within years, especially if you are aiming for "multiple standard deviations" above average. At the very least the practical generational span is 20 years, and usually much longer if the subjects have any say in the matter.
Genome wide association studies... another thing people get terribly confused about. The mutations they screen for are virtually never causal, but merely markers associated with actually causal sequences. There may be occasional better-researched mutations here and there. But overall the individual contributions of any such marker are already extremely low and don't sum up to a significant portion of the suspected heritability. And heritability of intelligence in Humans is another problem where people don't seem to understand what the research is actually saying. Whenever people say things like "IQ in Humans has a heritability of 40-80%", they are at best summarizing in a misleading fashion if not outright lying.
To my knowledge there are virtually no candidate genes/mutations proposed for genetic improvement of intelligence in Humans. Especially not with the confidence you'd need to even attempt this. Even without ethical considerations.
> The number of subjects absolutely does matter. Selecting mice for intelligence is all nice and well, but you have to breed thousands, and "discard" most of them. Both in traditional breeding as well as with genetic engineering, you have to have sufficient number of trials to conclude anything.
The number of 'subjects' is elastic. If applied to IVF, that's everyone who uses IVF. In embryo selection, you are selecting out of available embryos, eg 1 out of 5. With other techniques like ovarian biopsy or gametogenesis, you are potentially selecting 1 out of 100+. Hence, plenty of subjects.
> You can reliably quantify the intelligence of a mouse at a few weeks of age and breed it soon thereafter (though you would probably use that "IQ" to score its parents). You can't reliably quantify health and intelligence of a Human within years, especially if you are aiming for "multiple standard deviations" above average. At the very least the practical generational span is 20 years, and usually much longer if the subjects have any say in the matter.
All irrelevant, since no one is suggesting phenotyping. That's the point of the polygenic scores.
> The mutations they screen for are virtually never causal, but merely markers associated with actually causal sequences.
Also irrelevant. When you are doing prediction for selection, all you need to do is predict the one with the highest scores. There is zero need to identify even a single causal variant. GWASes are so predictive because the SNPs are in LD with the causal variants, and the LD does not change abruptly in a single selection step.
However, since you think that none have been identified, you should go read the appendix to Lee et al 2018, among other IQ GWASes, where they do estimates, and turn up scores of SNPs which have causal probabilities >90%.
Even if the first step is .25sd, then those people could maybe provide another .25sd and so on and on. A gradual increase simply dependent on previous GMO.
> Education is more a filtering mechanism than an enrichment mechanism. Panning does not create gold.
But the Bessemer process does create steel. I'll be the first to agree that education doesn't give much knowledge (apart from basic reading and arithmetic, which take a few months at most). But it gives you something else:
1) Ability to show up on time
2) Ability to sit still and do boring stuff for hours every day
3) Belief in importance of grades
Basically it's a forced personality change, turning children into worker bees. That's why it takes years and why it's so valuable to employers.
> The most elite scientists in the future will be far smarter than anyone who ever lived.
This doesn't necessarily follow. It assumes the variance on IQ will remain the same, but a (potentially large) part of the variance comes from genetic differences.
>Education is more a filtering mechanism than an enrichment mechanism. Panning does not create gold.
Teaching people to read and write and do basic arithmetic significantly improves their overall outcome by almost any measure you care to look at. How is this not enrichment?
Teaching does increase kindness and intelligence, however. Just as practise of difficult skills can increase ones abilities. Or have none of your experiences left you smarter than before?
Certainly, a natural-born genius raised by wolves wouldn't make any great contributions to mathematics. I suspect that what gets missed in the nature/nurture debate that the two are in a complex feedback loop, with the result being the product not just of nature and nurture but how the two interacted. I would think even if we run out of low-hanging fruit in optimising our biology, correctly tailoring education to temperament (or vice versa if that's how the societies of the future prefer to approach it) could be another huge area of advancement.
No doubt once we or our AIs understand the biology a lot more thoroughly the future looks bright. But it is not like getting to a new software company and speeding up the build times by 10x.
Whatever your normative beliefs, we do not live in unipolar world. Our options are constrained by our competition. If the west makes this technology illegal, we will eventually be in conflict in a technological landscape we are too dull to comprehend. After which our laws, traditions and values will enter the history books.
This argument can be used to create and justify a race to the bottom in any field. Whatever your normative beliefs, those people over there are barbarians and will destroy everything you care about unless you destroy it first.
Maybe. I actually do not believe it will be illegal.
More likely, it will be abused, come with some unforeseen consequences, and diverse.
Smarts will not be all that is attempted.
Augmentation by combining biotech with electromechanical will happen too.
There will be factions of various kinds.
Who says We will have any meaningful control over the really smart augmented people, for example? They may mature, look around at the mess and have very different ideas on how this all goes.
This is like a parody of every content-free guilt-by-association argument I've ever seen. Zero attempt to engage issues, obviously incoherent comparison with half-real historical bogeymen backed up by no attempt at argumentation... And really, you think early eugenicists were afraid Africans would become smarter than them?
A fallacious, inappropriate personal attack backed by implied, unjustified, blatantly wrong comparisons.
There are parts of the USA seeking GREAT education. We may see that trend change.
I just installed some advanced manufacturing equipment into a HIGH SCHOOL level facility.
That building has awesome tech in it. They've spared no expense.
Let's put it this way. I am a skilled manufacturer. Could prototype a ton of stuff in there. They are missing very little, and as I pointed out to them in a discussion, the very first projects should be to simply manufacture the fill in pieces of equipment. The facility is weak in some basic areas that are not hard to manufacture. We discussed the idea of having the students maintain and add to the capabilities over time.
Likely to happen.
There are pockets like this all over the place.
What we are missing is general political will. That's changing as we realize we've missed out on a whole generation of people. Didn't do these things, and the impact is profound.
Where can I find a list of these pockets so I can begin to plan to relocate myself so I’m ready to have children in a few years? Or even communities dedicated to sharing this knowledge would be a good lead.
Who are they trailing? I thought European countries regularly were ranked as the best education systems in the world. The US for higher education as well.
Singapore and East Asian countries/territories which share the same educational culture dominate PISA rankings, esp for math and science.
They constitutes all of top 7 in math and 6 of the top 10 (7 if Vietnam is included) in science for PISA 2015.
Vietnam, which is much poorer than Western Europe, shares a similar educational culture and performs much better than other countries at a similar income level.
Life at conception is a relatively new concept even in the catholic church. Up into the 70s many US priests taught that "the quickening" was the point of ensoulment. That changed with the legalization of abortion by the supreme court and the modern pro-life movement. Biblically, it is even more confused and the protestant (and southern Baptist) incorporation is similarly recent.
I agree that when the genetic markers of intelligence become better understood and gene-editing becomes cheaper, balance-of-power considerations will tend over time to push states to sanction gene-editing.
Two other options though:
(i) states will realise that a global competition in human enhancement is collectively irrational, and proscribe it through a robust international convention, e.g. as they have with chemical weapons, and nuclear weapons through the non-proliferation treaty
(ii) states will sanction, pressure - and even attack - those who launch mass human enhancement programmes, e.g. as they sometimes do with countries breaking out of the non-proliferation regime
i) states will realise that a global competition in human enhancement is collectively irrational, and proscribe it through a robust international convention, e.g. as they have with chemical weapons, and nuclear weapons through the non-proliferation treaty
(ii) states will sanction, pressure - and even attack - those who launch mass human enhancement programmes, e.g. as they sometimes do with countries breaking out of the non-proliferation regime
Possible, but I think this will be very hard, as it is ultimately a knowledge problem. Biology is like software in a way.
In the limit, I think we will know the causal variants (which we don't know now it is not necessary for selection but is for genetic engineering) and then it will be difficult to contain such information or capabilities.
Regardless, China does not appear to be interested in playing that game. As long as this is the case, the point is moot.
The difference is that unlike nuclear weapons you won't get broad majority support that this technology shouldn't be widely adopted.
When genetic therapies allow underperforming kids at schools to increase their test scores, or small kids to grow taller and play basketball with their peers, you'll have parents rioting to get those therapies for their kids.
It's not even in the same ballpark as chemical weapons. Everyone can agree chemical weapons are bad. Nobody is protesting in the street demanding their legalization. People who can benefit from gene therapy will be highly motivated and politically active.
Speaking only for myself, if you want to leave your kids behind that's fine but I'll pay every penny I have for them to have every advantage possible.
I think there's a difference between a gene-editing programme focused on giving everyone the genetic basis of a decently healthy life, and one that goes beyond that and has major geopolitical consequences. It's the latter that risks spiralling into a global bioengineering arms race, and which states might want to proscribe.
Do you want to live in a world where some societies are genetically superior to others, or where there's a constant pressure to upgrade the human species as quickly and to the greatest advantage possible?
It's interesting that you use an arms race framing for this, rather than a scientific one.
Let me ask you this. Universities and private schooling give a constant pressure for families to provide the best possible education for their kids, leading to constant competition for the best education since that gives a huge advantage in the job market over everyone else.
Why haven't we banned universities and private schooling then, since it gives just as much advantage as any hypothetical near term genetic engineering would?
1) education has been around for millennia, genetic engineering hasn't
2) there is a deep and wide-ranging taboo about modifying the human species, which there isn't about education
3) the gains from genetic engineering are potentially rapid and far in excess of what can be achieved through education
4) there is a potential for states to enter into a human enhancement arms races, and the possible consequences of this - unsafe testing, the complete transformation of the human species, gene-based weapons - are terrible
5) gene editing will amplify inequalities and create eugenic-racist politics, in a way that education doesn't
I think (4) and (5) are the most important reasons why we should be more careful about genetic engineering than education. Competition in education is harmless compared to a race to create the best superhumans.
Why on earth would countries want to limit improvements? We don’t see countries engaging in vaccine non-proliferation agreements, even though those are unevenly distributed. Non-proliferation is for destructive technologies.
However, as stated in a sibling comment, I think the advantages gained from IQ gene editing are quite exaggerated.
You're right. But denial is a strong force, and in big parts of the west, values that contract to biology have become socially sacred and impossible to contradict. Whatever communities think like this will cling to blank-slateism even as they lose political power, economic power, and ultimately, their standard of living --- because the alternative is, to many people, literally unthinkable.
It's tragic, especially because the stakes are high and advance permanent and self-reinforcing. How likely do you think it'll be that countries are able to catch to the newly-140-IQ first movers establish a lead?
Genetic modifications will go beyond human traits and variances relatively soon after they become available with relative safety. There is no reason people will not choose e.g. memory-enhancing modifications or huge life-extending ones. It will only take a few first experiments to have a new global "arms race". The fear of loss of power will easily silence most ethical concerns. In that respect western countries seem to have locked in the best scientists for that. There is no doubt that it will be a pivotal moment in the history of the human race (and probably the end of it)
Not really, at least with the current state of knowledge. There are very few genes where one can predict that altering them will increase intelligence.
There are hundreds, they don't need to be confidently predicted they just need to increase on average, and even if there weren't, all you need is a PGS for selection since a small predictive power is enough when iterated repeatedly.
A human isn't an embryo either, what's your point? You can do it every generation, and at some point 'generation' will encompass in vitro operations as well.
Interesting. My gut instinct is that Iran is a small country, but apparently my gut is wrong. It's in the top 10% by population and by area. [1] Of course "large" and "small" aren't well-defined. You could make a case that there are only two "large" countries (China, India) and all the rest are "small."
Are you talking about physical size? If so you forgot two of the actual largest countries (Russia, Canada). Brazil and Australia are also bigger than India.
I agree. Although the tech isn't there yet, it's rapidly coming. Whether the breakthroughs are two years away, or ten, or fifty they are coming. And discovery is accelerated by AI in looking for the solutions in biology. China is making far more investments in this area than is the US at the moment. A decent read from a few days ago: https://www.scmp.com/news/china/science/article/2174815/chin...
> Islamic culture, traditional scholarship places the point of ensoulment anywhere between 40 and 120 days after conception. Our western taboos around this topic, likely even our western secular taboos, derive from a belief in ensoulment at conception.
Changing the creations of God is still very much considered forbidden in the religion. Also many scholars would still consider e.g. abortion without valid reason before ensoulment as forbidden. Personally I think the Islamic world would wrestle much more with this than any other.
I agree with you, and I think it is telling of how warped this debate is by normative viewpoints that such a high percentage of reference sources and arguments come from one highly independent and active source (gwern). Aside from the detail of the argument, if you're observing a debate as an outsider, and you're interested in how the world actually is, it is often useful to kind of subtract an estimate of how people would like the world to be from the consensus.
Your citation is quite critical of IES as a profitable enterprise along the lines of traditional tech companies. Concretely there are enormous challenges before it is applicable to humans and could be sold as a service. Instead it seems likely that large groups would federate to share process etc, eg at the level of EU to ensure that broad economic community benefits and not just the 1%.
> even a smallish one like Iran say, would quickly be producing the vast majority of all genius-level intellects.
Wait, by this logic China and India should be currently producing the majority of genius-level intellects. Are there really 5 times more geniuses in China than in the US? If not it means education and infrastructure plays a part.
The population ratio were already the same. Assuming the average human IQ is the same, that would mean for the topmost 10 000 brilliant American geniuses, you would have about 50 000 Chinese geniuses of the same caliber. Or that there are as many people in China that are in the top IQ percentile as there are people in the US that are in the 5th percentile.
I have no idea if this is true or if it has a sensible impact.
Evolution is a massive parallel computation system using heavily bummed code. Nobody really has any idea the value of any gene (much less how it interacts environmentally) on a systemic level.
The cost of wiping out depression could be a lack of creativity. Which will be more valuable in a society 30 years hence? Nobody has any idea of course; that's the value of evolution: it continually run a set of multivariate experiments.
Good luck to you and your kids; I honestly hope it works out well for you all. But based on centuries of fad "engineering" mostly at the environmental level (teaching, nutrition fads) it all below the noise floor.
For the reasons you suggest it's likely that any safe useful embyronic editing will make it to the global mainstream within a generation or so.
This will have some interesting consequences for the future of our species. Greg Bear's "Sisters" (collected in "Just Over the Horizon") took a compelling angle on a world with ubiquitous genetic editing of embryos. He made a few predictions:
(1) People whose parents opt out of the process will, indeed, have worse social lives, worse careers, and worse lives overall -- they will get sicker, die younger, and be less prepared for exceptional performances. Bear uses the lens of high school where everyone feels like they don't fit in but convincingly suggests that non-edited people would feel worse.
(2) Most "pre-planned children" (those subject to embyronic editing) will get a combination of a handful of known safe "packages" which will probably be iterated annually by the companies who offer them. This means in practice that most people born in the same year will have many similar traits and quirks.
(3) People will not, by and large, physically resemble their parents; desirable traits will include appearance. They will, however, all kind of look like one another.
(4) People who opt out of the practice despite having enough money will be seen as quirky anachronisms from another era.
(5) Inevitably someone will mess up and some trait will enter the mainstream which causes widespread calamity -- for example, 50% of people aged 15-16 who was built in a certain batch will suddenly die from a previously undiscovered anomaly. This will be treatable with CRISPR-style technologies and folks will rush to build a treatment the first time it happens. These mass deaths will come as a surprise because, while in some sense we know we are doing something different by imposing relatively few features on a relatively large population and by bypassing tens of generations of random mutation, we don't really understand what we're "losing" by skipping the normal process that selects for viable individuals.
Bear theorizes that it's going to be important in a few decades to remember that everyone, both the pre-planned people and the unedited people, is human and deserves equal dignity as a person. He tries to end the story in an upbeat way when his protagonist addresses the surviving half of her graduating high school class:
""
"This has been a bad time for all of us," she began, voice high and scratchy. She cleared her throat. "I've lost a lot of friends, and so have you. Maybe you've lost sons and daughters. I think, even from there, looking at me, you can tell I'm not ... designed. I'm natural. I don't have to wonder about whether I'll get sick and die. But I ..." She cleared her throat again. It wasn't getting easier. "I thought someone like me could tell you something important."
"People have made mistakes, bad mistakes. But you are not a mistake. I mean ... they weren't mistaken to make you. I can only dream about doing some of the things you'll do. Some of you are made to live in space for a long time, and I can't do that. Some of you will think things I can't, and go places I won't ... travel to see the stars. We're different in a lot of ways, but I just thought it was important to tell you..." She wasn't following the prepared speech. She couldn't. "I love you. I don't care what the others say. We love you. You are very important. Please don't forget that."
""
Not really sure what the broader lesson is, but the story stuck with me and there are a couple of specific predictions in there that will be interesting to see tested out in the next few decades.
Bear is a good writer, but his genetics are shaky... #2 and #3 are just silly. Doing a little embryo selection or even editing is not going to lead to a race of pod people who all have the same hair style and prefer Earl Gray tea.
Appearance is influenced by millions of variants, which have little or nothing to do on average to do with the variants which influence traits like intelligence (the genetic correlation is ~0 - you don't see genetic correlations between intelligence and well-predicted traits like hair or eye color being reported in the literature).
Even if the same genetic variants which influence something superficial like facial bone structure also influence neurogenesis etc, any editing or selection making people more similar will just be a drop in the pond. Think about siblings: compared to 2 random people, siblings are more similar on what must be tens of millions of genetic variants, and yet, consider how completely different siblings often look, act, and turn out! (Jencks, I think, in _Inequality_ points out that there's almost as much 'inequality' in life outcomes like income within American families as there is across families.)
Further, let's say that all of that turns out to be wrong; nevertheless, parental relatedness to children is desperately desired by parents and this is a major reason why sperm/egg donation are profoundly unpopular and why parents have such stringent demands of donors from banks and why people will deliberately select embryos with Huntington's and other serious disorders if the healthy embryos fail to yield a live birth. It would be entirely possible to simply tilt the selection or editing to preserve relatedness to parents on visible attributes - 'relatedness to parents' is simply yet another metric to optimize for, thrown into the stew with the usual ones, and it is one that parents will put a high value on even at the cost of some potential gains on other metrics.
(#5 is also quite problematic as it assumes that completely novel edits will be done on a mass basis without any kind of testing. In reality, everyone will focus on variants that already are widespread in the population and which are already being tested in the real world. It's the rare variants which are harmful, not the common ones.)
It did make me wonder about the important aspect that the Edited humans will likely also feel Love much the same as normal humans. This might help the whole situation, if we define Love as some combination of Empathy and Desire for the other Individual to thrive (for selfish reasons). I'm trying to say that - the other way around from that speech is interesting. If the Designed decide that they Love us the Undesigned, we might be saved from destruction or even an extremely worsened life quality.
There are two caveats:
1. Love could be seen as a 'weakness' and there might be a crop of super genius Designed who don't have the genes required. If it turns out that this does not impact viability for whatever reasons, natural or engineered (we design companies where we expect some geniuses to be Complete Jerks and be okay with that as long as the bottomline is improved), then the undesigned are doomed.
2. Love does not fix all problems. There are Homeless people in San Fransisco despite being surrounded by some of the smartest, richest people who also have Empathy and Love for people in their lives. But enough of these Smart Rich People would prefer the Homeless just go elsewhere rather than blot the landscape (instead of thinking about helping them) - that there's no political will to aggressively fix the problem. The Undesigned could just end up being the Homeless of the near future. Fun Times (I'm terrified).
people like me (who think inflicting stupidly and ill-health on their children by withholding these technologies is morally wrong
The argument is not simply about "withholding" these technologies, but (as the article title explicitly says) restricting them to the rich.
These are complicated ethical issues (that judging by some of your comments in the thread you are very able to debate clearly, knowledgeabley and intelligently) that are not served in discussion by misdirecting the question.
Countries which aren't run by tyrants will not engage in these sorts of experiments. Any free-thinking scientific community knows the risks vastly outweigh the benefits, and will continue to do so for a long time. Surely you can see the biggest problem is that IQ is a surrogate of what we actually want, and if you start editing to achieve that, you could easily end up with people that are world class at guessing the most obvious next number in a sequence, but will never discover anything.
What is likely to happen is that somewhere like North Korea could start trying it. If they get far enough into it, they will probably realise super-intelligent people don't want to hang around in totalatarian regimes run by fools, or swallow propaganda. Either they will find a way to make super-intelligent psychopaths who are naturally gratified by participating in world-denomination skullduggery, or they will engineer them to be somehow dependent on the regime, perhaps introducing a disease that needs some hard to acquire maintenance therapy.
I hope your balance of power theory has been mulled over at the pentagon. We need the best propagandists we’ve got keeping that taboo as strong as possible.
They are welcome to try. But it seems unlikely to work on China. If I was trying to maximize Chinese future influence I would do my best to support the unscientific Lysenkoism of the mind that is so fashionable in the west and so completely out of fashion in China.
The current fashion among the right-thinking in the west is to assume all characteristics are genetically heritable save for mental traits like intelligence, hand waving the twin studies which proved pretty conclusively that a huge portion of intelligence is genetically heritable.
Darwin won the body, Lysenko the mind.
Cognitive genomics is already heightening the contradictions of this view. Eventually it will collapse.
You understand that the difference in intelligence between humans and chimps could well be 100% genetic and the difference in intelligence between a poor town and a rich town could be 100% environmental, yeah?
But the individual is never the focus on these arguments. You refer to countries having higher intelligence. We have many towns where I live where education and smarts are mocked. The countries with higher intelligence revere education and ensure children are cared for. And the genetic component of the principal factor of taking intelligence tests as children could easily be weird traits like a slower rate of neuronal death during adolescence or not having a fear. Also most of the tests can't actually get a good number for individual variance due to the many subgroups with many related environmental factors. So you have a mathematical artifact of tests with poor experimental conditions getting .6 to .8 hereditabilty. And then you claim we can make a population that is multipme standard deviations away from the biological norms? It seems like a cool sci-fi stretch more not public policy ready.
How do you explain the rise in IQ scores over time ? Better genetics?
True. I guess my point is that intelligence being heritable in individuals does not directlt imply that we can now use genetic techniques to improve the average IQ. Inheritability is perfectly consistent with the group average (modulo the environme t) already being as high as possible. 'Too many people with eidetic memories and the group looses topological intuition. Too many Gauss level brains and we lose the ability to do carpentry or CSS.' Maybe not but the evidence needs to be shown. Extraordinary claims and all that.
>"my point is that intelligence being heritable in individuals does not directlt imply that we can now use genetic techniques to improve the average IQ"
Depending on what you mean by 'genetic techniques', it sure does. Here's a genetic technique: Test everyone for IQ and only breed the top ten percent. Average IQ will obviously improve. This is just old fashioned selective breeding. It can be done, and in fact has been done (unintentionally) in places like Israel, where average IQ is notably higher.
Whether that would unbalance society in some sense ("lose the ability to do carpentry") is another question.
I think society is actually unbalanced now; we have more stupid people than we need because new technologies have shifted the IQ demands upwards. There's no use for dumb brutes any more; we have machines to do the physical work they used to do. But we have tons of use for smarty-pants; so much that we can't get enough of them. Increasing average IQ wouldn't unbalance society; it would re-balance it to the new demands of the modern world.
Unless you think mind skills/IQ are determined by just 3 or 4 genes you will be very sad at the rate of genomic shift by selective breeding. Elsewhere people are claiming hundreds of genes. That is looking at hundreds of generations to remove the weaker version even assumong you have only a bad dominant version and a good recessive version. One generation to eliminate all the bad dominant copies for one gene. And at the cost of reduced genetic and mental variability which seems likely to reduce population fitness.
however, the current picture of vertabrate development makes it seems like such a simple genetic model for mind skill traits is hopelessly unlikely. You have weird crap like receptors being used for different functions in different areas of the brain. And they migrate / gene activate at different times of development in response to genetic expression partially determined by environmental conditions. Its a big ugly undocumented hack. I tend to assume we are all SWE but if you are not, there is human created code so unmaintainable the cost to fix/understand is easily 10x the cost to create. Evolution i guess has no reason to make it easier on gene engineers. Unless you hope the human brain ends up being kike particle physics with a few elegant math laws that make the apparent complexity simple.
That's not how selective breeding works. There's no rule where it takes one generation per gene. With a large population you can find individuals who gain many generic improvements in one generation. With sexual reproduction you can combine advantageous gene lines. Finally, note that we're starting with a huge amount of diversity so we don't need to create new genes, just select the best ones we already have.
That article cites the Williams Group, which appears to be some sort of consultancy with the tagline "we prepare heirs."
This isn't the first time I've heard the 70% number, and I've never been able to find a single scientific study supporting it. There's also never any clarification on what "rich" means, or what qualifies as "lose their wealth."
Becker, Gary S & Tomes, Nigel, 1986. "Human Capital and the Rise and Fall of Families," Journal of Labor Economics, University of Chicago Press, vol. 4(3), pages 1-39, July.
"The authors examine a number of empirical studies for different countries. Regression to the mean in earnings in rich countries appears to be rapid. Almost all the earnings advantages or disadvantages of ancestors are wiped out in three generations."
> The authors examine a number of empirical studies for different countries. Regression to the mean in earnings in rich countries appears to be rapid. Almost all the earnings advantages or disadvantages of ancestors are wiped out in three generations.
That's deeply at odds with what I know about the world (think about the existence of the "middle class", and how middle class parents tend to have middle class children). That, and the fact that the article was written by Gary Becker (he of "all crime is a rational cost / benefit tradeoff" fame), and published at a time when economists did very little emperical work, make me more or less immediately dismiss the claim.
But if anyone could give me the gist of the argument they make, I'd love to be proven wrong.
My guess is that you can put the bar for "wealthy" as high as necessary to get any percentage you want. Illustrating by reductio ad absurdum, you can make the argument that 100% of "wealthy" parents have no wealthy children, if your definition of "wealthy" is only the single richest person in the world. Expand the definition incrementally, and you can probably get nearly any percentage statistic you want between 10% and 100%. So the fact is "not even wrong" without more context.
That implies that it has to do with genes in the first place. Perhaps there's an argument there. However, I would also consider that the size of an estate may grow, but not exponentially (at least not indefinitely). Yet, the size of a family tree does grow exponentially.
Be very careful what you wish for. There is some evidence that debilitating, even deadly, genetic disorders correspond to higher-than-average intelligence.
Only about 2% of the U.S. population is of full Ashkenazi Jewish descent, but 27% of United States Nobel prize winners in the 20th century, 25% of the winners of the Fields Medal (the top prize in mathematics), 25% of ACM Turing Award winners, a quarter of Westinghouse Science Talent Search winners, and 38% of the Oscar-winning film directors have either full or partial Ashkenazi Jewish ancestry.
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Today's Ashkenazi Jews suffer from a number of congenital diseases and mutations at higher rates than most other ethnic groups; these include Tay–Sachs disease, Gaucher's disease, Bloom's syndrome, and Fanconi anemia, and mutations at BRCA1 and BRCA2.
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At least one of the diseases in this cluster, torsion dystonia, has been found to correlate with high IQ.
> Only about 2% of the U.S. population is of full Ashkenazi Jewish descent, but 27% of United States Nobel prize winners in the 20th century, 25% of the winners of the Fields Medal (the top prize in mathematics), 25% of ACM Turing Award winners, a quarter of Westinghouse Science Talent Search winners, and 38% of the Oscar-winning film directors have either full or partial Ashkenazi Jewish ancestry.
So what percentage of the population has partial Ashkenazi Jewish ancestry?
That's a really good question. I can't immediately find an answer.
What I can find is data that says Jews have won 22% of Nobel Prizes globally while being only 0.2% of the global population, but that starts getting into "how to lie with statistics" territory because I imagine few such prizes go to people in developing countries. So I think the American figures are a more good faith attempt to quantify the known fact that Jews are seriously overrepresented.
It’s also possible that these smart Jews have biased towards investigating and inventing more disorders surrounding their own population than other ones.
Is that really due to intelligence, and not systemic bias/a 'pipeline problem'? 25% of Harvard students are Jewish [1,2], and "all eight major film studios are run by men who happen to be Jewish." [3]. So of course if they're so over-represented in education and film, they'd be over-represented in education/film awards as well.
At least that's certainly the argument everyone would be making if you swapped which ethnicity is 'superior'...
Jews are one of the historically most oppressed minorities. So if they were able to succeed so much, does that mean latinos or blacks are just too dumb to do the same?
Once you accept success as proof of intelligence, there's no end to the 'fun' conclusions you can draw!
The concept of "Ashkenazi Jewish" does not correspond as strongly as you might think to a homogenous genetic make-up. Ashkenazi Jewish people come from a wide range of European and Middle Eastern genetic make-up, and you'll find as much diversity within Ashkenazi Jews as there is between Ashkenazi Jews & Europeans / Ashkenazi Jews - eastern Mediterranean basin. The higher rate of heritable disease is due to isolated communities marrying lots of first cousins etc (historically speaking). But there were many such dispersed & distinct such communities.
I wasn't suggesting that the term corresponded to a homogeneous genetic/ethnic makeup. I was only suggesting they win a lot of "smart people" type awards and also are known to suffer at high rates from genetic disorders.
This argument never made much sense to me because overall IQ is correlated positively with health and longevity. Sure, it might change the nature of the afflictions we get, but mostly this just feels like an argument from just comeuppance, when in reality nature doesn't give a damn about being fair.
I used to be involved in the online gifted community. Slightly above average IQ is correlated with generally doing better across the board. "Genius" type IQs are so strongly associated with a raft load of various problems, such as ADHD and OCD, that some people call them comormidities for lack of a better word.
The information stuck with me because I have a genetic disorder and was one of the top people in my graduating high school class and won a National Merit Scholarship. I'm certainly not looking for some "gotcha" for smart people, just trying to make my own life work.
I know a bit more than average about both genetic disorders and high intelligence. My knowledge of both is certainly not motivated by some ugly impetus.
It's unreasonable to expect initial modifications to start out as swathe modifications summing to tens of IQ points. The first gene modifications are going to be fixated on the safest changes that can be made to health and, along the road, things that correlate most convincingly with IQ and positive outcomes.
We'll only see increases in base rates of geniuses born at this point as an incidental byproduct of moving the line one step closer. The average person undergoing these modifications will be better off for it, and early failures will predominantly be due to issues in doing these modifications well, not intrinsic negative byproducts of IQ enhancement.
This is all speculation, but it makes more sense to me than how you presented it.
IQ tests have problems, but aren't completely useless. But it means there's always some legitimacy to the argument that "Them that has, gets" aka that it's cultural, it's "who you know, not what you know" etc.
People with "very high IQs" fundamentally approach problems differently from others. They aren't trying to build a better metaphorical apple. They show up with an orange instead.
Your idea of "better" doesn't really parse for me. A bird flies better than a fish. A fish swims better than a bird. But a (gilled) fish out of water will soon die from lack of oxygen.
When you modify genes, there is one certainty: You are changing things. There is much less certainty that you are changing them for the better and my understanding of life, the universe and everything suggests it's probably deluded to believe you can change things for the better with zero downside.
It's this core idea that compromise is equivalence that I was arguing against. You're comparing the fish with the birds, but you're forgetting the other fish that got infected with some specific disease before going extinct. Humans are new, living in environments a thousand times newer. There is very little reason to believe that we've hit a local optimum, and a lot to believe that some mental characteristics (like being in the bottom half of aggressiveness) would be pretty much universally positive.
Oh my god the hubris. You want to start engineering out agressiveness potential? Given that genes code for a system that is then trained by experience maybe you want to tweak the training set first.
Malaria vaccination/parasite elimination/even vector elimination would seems to have a different risk/cost/benefit profile than removing, without anfull knowledge of the biology or the social stability implications, a defining emotional/mental characteristic of our species. But whatever, maybe you plan this change just for the "betas and gammas" we alphas can keep flaming away.
Before genetic modifications we should try cloning people (especially famous scientists) to see how much of IQ is genetic, and how is it affected by the environment.
Be very skeptical about wearing mental disorders as honor badges. I was a higher-than-average IQ kid, but it wasn't because of greater intelligence, but because I was introvert, and introvert hobbies usually make you score better at traditional IQ tests.
I said "was" because I don't think I'm more intelligent than average. Personally, I think IQ tests are bogus because the more you take, the higher your IQ becomes. It's not your intelligence that grows, but your understanding of what IQ tests expect of you.
Be very skeptical about wearing mental disorders as honor badges.
I was involved with online support groups. These were not people looking for bragging rights. They were people trying to make their lives work and finding that their differences were a significant social burden that was often threatening to outright ruin their lives.
One point of clarification: I don't have a mental disorder. I have a genetic disorder, which is a serious medical condition.
My original assertion was that there is some evidence that some genetic disorders correspond to higher IQ. I stand by that.
The detail about the more well established pattern that issues like OCD are known to be a problem for people with extremely high IQs was introduced to rebut the idea that the lives of "smart people" are globally better in every way from that of "average people." But replies focusing on that seem to be moving the goal posts, which makes it difficult to meaningfully engage.
The general form of this problem is that the correlations, including things like retest and test-to-test repeatability, all come from the fat part of the curve (say +/- 2 sd). But people love to extrapolate those findings to the part of the tail where there is no good data.
I think you are maybe conflating people with slightly higher than average IQ's, like those who maybe were in NHS in high school or something, with geniuses. They are not at all the same thing.
There's a lot of debilitating ailments when you start getting into the top half of the 1% IQ elites. There are many people looking into the why's? and the how's? of that, because it is absolutely something that we should be trying to get a better understanding of.
To be clear, I'm not denying that genius correlates with certain mental afflictions. I'm denying that this should be a major reason to be concerned about IQ enhancement through genetic modifications, and would add to my original point by suggesting that there are clearly also ways for people to attain exceptionally intelligent brains while not having these issues (since many examples exist), and it is not at all obvious that we couldn't purposefully aim for that space.
Safe to bet if our biology was easily tweaked to make us all super smart without cost evolution would have found it. Engineering is all about trade offs. And having people of differing abilities seems to make groups stronger and more likely to survive.
This is only true is you assume that higher IQ necessarily improves reproductive volume in ancestral scenarios. There's no reason to assume that. IQ just wasn't that useful until very recently in history and would have been detrimental in many ways.
What is a genius going to do with all his smarts if he's born to illiterate medieval farmers or tribal hunters? It just means he'll ask questions that annoy people and get distracted by reproductively irrelevant thoughts. There's no math to do, no books to read, no machines to improve, no big complex systems to understand. IQ is not historically adaptive in the evolutionary sense. If it was, we'd all be a lot smarter.
If you doubt this, just consider animals like chimps, dolphins, or elephants. They could have evolved higher intelligence, but it was more adaptive for them not to.
Depending on what you consider cost, I might take the other side of that bet. A huge cost of higher IQ is probably the higher caloric requirements for a more effective brain, but that cost is fairly incidental given our new environment. There may well be other, similar examples.
We didn't do anything. Evolution is a relatively efficient searcher but a very bad respector of modern systems design principals. Each chemical pathway has a tendency to be tied to multiple unrelated systems. The genome itself is only for a developmental system/architecture largely consistent across the vertebrates. We could try surpressing say visible agression traits and discover 50% of the folks die in their fifties due to some previously unknown liver metabolism or get super depressed when their kids grow up or get phantom limb pains. If some one gene swap would make people 10% smarter and not kill their groups off faster, odds are we have the better gene. Biology is just a lot more complex than code, or vaccines. I mean i might be wrong maybe increasing "fitness of mind" will be as easy as a smallpox vaccine. But i haven't read any genetic or proteomic stuff that makes me say, oh wow this is simpler than we thought. What i see is people building software to get a grip on the complexity of these systems.
We'd only likely see huge consequences like that if we went outside the normal range of human variation. I agree that evolution would find single gene swaps with huge effects, but most of the variation available to us is over hundreds or thousands of genes making incremental effects. This is why I think we're probably first going go be able to effect marginal shifts in the overall distribution of these traits, not large jumps.
bearing in mind that large jumps have different causes than marginal improvements, I'd agree. And I'm putting my money on the Ship Minds anyways. Biology seems too complex for even top humans. : )
Eliminating mendelian disease is on the table too. We are on the verge of getting gobs and gobs of selection power. This will allow us to select on multiple dimensions simultaneously.
And there are no cultural or familiar practisces that differ between Ashkenazi families and more typical US families? Go read five biographies of these Nobel prize winners and read about the family influences.
how about the hubris that we could ever possibly know what the "best" genes are, save whatever is currently desired for our current, extremely limited viewpoint on what "best" is. It's like reaching a local maxima and thinking you found the peak, but in the grand scheme of an evolutionary timeline were a factor of 100x away from what the real "best" was
That's the thing with evolution, it's all about the ability to adapt.
Caveat being that you never know what adaptation you'll need until the shock arrives, and at that point it's too late. At that point, you either have the ability to adapt, or you don't. Nature doesn't care if you're the smartest, the strongest, the healthiest, the most whatever. Doesn't matter to her. Can you adapt to this different environment or not? That's all that matters.
Your average physically fit female would have been dead after less than 15 minutes in the water after Titanic went down. Lower body fat percentage, etc etc etc. At the same time, the portly, out of shape, and perpetually drunk chief baker lived in the water for over 8 hours. Now that's not an example of evolution or anything, but it does illustrate the value of adaptability when shock radical change occurs. The chief baker's body was able to adapt to a radical change in environment, everyone else' was not.
“Best”? No. But evolution isn’t even trying, and only gave us what we have by trial and error. Most of those errors are worse. We’re descended from the mutations which were not worse, but every mutation was random and unplanned (by any reasonable use of the word), all the way back to the primordial soup.
Evolution is largely a winnowing process. What doesn't die before it can successfully reproduce "wins."
This is the explanation behind genetic disorders being more common in certain populations. Sickle Cell Anemia (2 copies of defective gene) is terrible, but Sickle Cell Trait (1 copy) protects against Malaria. Having one copy is advantageous in areas where Malaria is endemic.
But I wouldn't go so far as to say evolution isn't even trying. Bacteria apparently produce more mutations than normal in hostile environments, apparently a form of gambling on anything being better than what we are d meoing currently.
hmm. this view is superlimited. we understand how evolution works and why it happens but the arrogance to believe we could do better is definitely a human trait.
It may be a human trait, but it really isn’t arrogance. Even without fully understanding the consequences, the fact we have a purpose in mind a massive improvement on evolution.
not understanding the consequences and/or performing changes at a fast pace without giving either the species or the environment time to adapt is what gets you extinct
99.9999999999% of species go extinct because evolution didn’t and inherently couldn’t prepare them. Evolution has all the flaws you ascribe to mankind and more besides.
evolution does not prepare you. evolution does nothing. the changes that occur in order to adapt to the environment are what we call evolution. The problem is that the environment does not change (most of the times) suddenly so the fitness function of the individuals can be verified (again most of the times) against the environment for many, many generations. Once you start throwing away validation and you also have a species that has a long lifespan (ie humans) you are throwing away the validation safety net. Sometimes 10 years will pass until you notice something is wrong. Sometimes 50. Even worse, the genes that you are experimenting with will live in the wild and will also get to reproduce/mutate freely. New diseases? Zombies? Superhumans? who knows?
My point is that we are not knowledgeable and qualified to play God yet. We will definitely do it and we will invariably fuck it up. That does not mean we should actually attempt to do it.
What you call “validation” ceases to occur after reproduction. My mother and my grandmother on her side both developed Alzheimer’s, which is 100% because evolution hasn’t got a plan and doesn’t care because it’s incapable of planning or caring.
My point is that evolution is not qualified to play god, unless by “god” you mean Azathoth.
"Validation" == you reach reproduction age and you actually live long enough after that to see your offsprings reach reproduction age.
Evolution is not qualified is the traditional sense, because its goal is not to play god. It's qualified in the sense that this is a side effect of evolution.
Once you throw away the safety of this "validation" and it takes a long time to actually understand what the effects are you will see in some cases the disastrous results of what you're doing
They are rich - I don't have the confidence that they can be stopped in this age of lopsided wealth/power concentration. Better to let them be the guinea pigs evolving the technology to become stable and inevitably common. When everyone is able to buy genes, we will all be at a new square one.
I'd highly recommend Radiolab's "G" Series of mini-podcasts that cover material pretty pertinent to the discussions in these comment sections. I really enjoyed the entire series. Here is the abstract for it:
Radiolab’s “G” is a multi-episode exploration of one of the most dangerous ideas of the past century: the concept of intelligence. Over six episodes, the series unearths the fraught history (and present-day use) of IQ tests, digs into the bizarre tale of one man’s obsessive quest to find the secret to genius in Einstein’s brain, reveals the ways the dark history of eugenics have crept up into the present, looks to the future with a controversial geneticist who has created a prenatal test for intelligence, and stages a raucous game-show throwdown to crown the smartest animal in the world.
There are superior gene combinations that are not known or are poorly understood, such as high bone density, resistance to acute radiation exposure, faster environmental adaptability, greater pulmonary volume. By higher bone density I mean 3-5x greater than normal. These supposedly superior conditions are things that actually exist and boost performance, but they also impose stress on other health systems. After accounting for complexity superior is in the eye of the beholder after consideration for what factors/goals are most desirable.
Strong bones but death st sge 50. It will take as long as fifty years to learn that. Or maybe this system will be easy to fix forward and hack. I mean evolution is clearly going to result is modularism as a design principal and separation of functions of chemical pathways. Not like hacking some hand crafted assembly code by a dead mad genius, it wont be like that.
Is this even possible? Buying the best genes as if you could buy an Armani suit.
What this should say is "Should the rich be able to saddle their children with untested, unproven genetic technology in the hopes they can select for traits that give them competitive advantage in their social world, no matter what the side costs are?"
The answer should be no. If you want to breed children like show dogs, it doesn't matter how smart they are in the end, you've diminished them.
Perhaps a different way of asking the question is 'will the rich be buying the best genes?'
And the answer is 'yes' because they already are, in limited ways.
But we may be overlooking the breadth of the 'rich' in the future. Most humans today are far more rich than anyone else alive in the recent past. If this trend continues into the future, the accessibility and affordability of gene selection will make it commonplace.
The bigger issue seems to be determining what "best" means.
While there are a handful of diseases associated with specific genetic variants that could obviously be cured, the traits people would likely try to optimize (e.g. intelligence) seem to involve a complex combination of genes and environment, and an attempt to select for such genes could incur some potentially negative side-effects.
It seems like your two sentences don't really fit together.
"Best" pretty clearly means higher IQ in this context.
The fact that the practical engineering required to accomplish that will involve setbacks, failures, costs, and suffering doesn't mean that we can't define the goal.
Agreed that intelligence is a good thing, but the question is about whether there is a set of genes that are “best” for producing it. At the moment it’s unclear which genes those are, and even if we found some genes related to intelligence, they may have other negative consequences that make the idea of a “best” set of genes questionable
Yes, there is surely evidence that intelligence is heritable, but it's worth giving the research on this a close reading. Current approaches can only explain 10% of the variance in intelligence (https://www.nature.com/articles/nrg.2017.104), plus the effects from the environment. My main issue with the article though was the assumption that a "best" set of genes exists without futher discussion (in addition to obvious ethical concerns)
I was just responding to this: "intelligence is a good thing, but the question is about whether there is a set of genes that are “best” for producing it. At the moment it’s unclear which genes those are"
Basically just noting that we now know at least some of those genes.
Many more will be found. Some will have other deleterious effects, and we'll figure that out too. The cause-and-effect of genotype and phenotype will be slowly decoded. It's just a matter of time; there's nothing unsurmountable here at all.
Look at it this way: a lot of smart people contribute to common goods, e.g. scholarly progress. So in a way, it'll benefit everyone.
I understand the counter-argument. But isn't a bit of a strange feature of the world that people kinda don't want more people to be produced with a higher IQ than themselves?
Genius-level heirs who aren't psychopaths would be a great thing actually. If we had this a generation ago, maybe our leaders would have been smart enough to act responsibly about climate change.
Having your tuition paid for does not equal getting the best education. Lots of dummies graduate from the world's top schools simply because of pedigree.
This guy thinks gene A makes you smarter, gene B makes you stronger, gene C makes you taller. And then rich people will buy gene A, B, C and become smarter, stronger, taller, and then richer still. And poor people will be poor forever.
In reality gene A makes a protein a, which triggers an increase in the expression of genes B,C,D, and a decrease in the expression of genes E,F,G. They in turn trigger other and other effects, so there's a cascade of cause-effects that we have no chance to model/simulate/understand, at least not now, and not in the next 30-50 years. The end result is that gene A may make you smarter, but also more prone to macular degeneration or leukemia. Do you think rich people will take the chance ?
People don't seem to be talking about Crime and Policing, btw. If Criminals get super-intelligent, then we are going to need super-intelligent Policing. This is a smaller fractal of the Military competition aspect, but the dynamics are similar. Ultimately, once this tech becomes reality, it will be impossible to contain for this reason alone. You can't have Enhanced Cops themselves imprisoned in a way that they can't spread their genes.
Someone has to beta test genetic enhancement before it becomes mainstream. If it is currently expensive, only the rich can pay it... or pay other people to be the guinea pigs.
It understandably hurts traditional western sensibilities, but genetic engineering is the inevitable cusp of evolution. At the base it's natural selection, then civilization added social selection on top, and finally tech will finish the pyramid with genetic engineering.
I attended Isaacson's Aspen panel on CRISPR this June. He said his next book is on biotechnology. He wrote the definitive biography of Steve Jobs and some major scientists.
No. I don't believe Human gene-editing will enhance socio-economic divides. For one thing genetic enhancements is incredibly hard. There will always be some risk of side-effects. Even without side-effects there will be huge problems in coordinating multiple changes and making sure they are actually beneficial. This is especially so for traits like intelligence. And you don't get a do-over in Humans. If the treatment doesn't work as intended, you still have a child.
We're very far from routine genetic enhancements. Multiple Decades, in my opinion. Even single-mutation treatments for serious diseases should not become routine in the next 10 years.
On the other hand these treatments could be relatively cheap, once the technology has progressed far enough. At the very least, it would be beneficial for any society to pay for any health- or intelligence-improving treatment for any parents who want it.
Next issue: Virtually any improvement in Health, especially during childhood, will lead to higher intelligence, body height and muscle mass. The reason is that the foundations for those traits are "grown" in a specific period of time, using the resources available. If a child gets less nutrition, less time in school or gets sick, those traits are negatively affected. That means not only gene-treatments improve intelligence, but so do vaccinations, antibiotics, antihelmintics and better hygiene.
You're right in the sense that these genes will propagate into the rest of the population. However:
1. Rich people are more likely to get into a relationship with other rich people.
2. At least for the next 100 years, it's likely the tech will improve at a rapid rate. That means by the time those high IQ genes spread to children, we will already have identified even better genes. People who can intentionally apply this technology to their designer-babies will stay ahead of the curve.
3. Sexual reproduction is a random process. If we begin to understand genetics well enough, we will almost always be able to get a better, more effective combination of genes by hand-picking them (or letting a computer decide) than by letting sexual gene recombination spin the wheel of fortune.
We're definitely looking at a future where the ruling class will have a huge genetic advantage, and will be able to maintain that advantage because of the huge cost associated.
A counter point, it seems that wealth and the power it provides already provide such a huge advantage that the effects of genetic editing may end up being a negligible.
I wonder about the preservation of wealth though. As other posts have pointed out, most wealth is lost within a generation or two. Genetic engineering could end up being used to modulate risk taking behavior and decision making, in an effort to mitigate this. That could have a big effect on the structure of society if successful...
Right now, in America and Europe, if you work hard, you have a decent shot at becoming wealthy, or upper middle class. Once genetic engineering enters the picture, wealthy people will have a genuine intrinsic advantage.
True, and to add one more point, poverty presently brings a along environmental factors, such as stress, toxic exposure, poor nutrition, that tragically impact brain development and leave people with an analogous intrinsic disadvantage later in life. On a positive note, I think these things are well within reach of fixing in our society and leveling the playing field.
In 25 years a woman might get this letter in their mailbox after a night with a rich guy: "You are pregnant with patented genes, pay licence fees or be forced to abort the child."
The Free Software Foundation has just released the full sequenced genone of Richard Stallman under the GPL. However, the download volumes have not matched the bandwidth used by Hurd.
I wonder whether anti-vaxxers are against gene modification or not? On one hand, their children may truly be immune and not need vaccines. But on the other, they might think the procedures will give them even more diseases.
Didn't bother to read the article, because the title seems silly. Firstly, we don't have a clue about the genetic architecture of intelligence, so genetic engineering is a ways off. Secondly, what is GRM ("Genetic Rights Management") going to look like? Copy-protection of genes almost seems like a contradiction in terms.
GRM can be as simple as a corporation owns rights to certain genes and thus owns a part of the income of those who happens to have these genes. Yes, children inherit the genes and thus owe to that company. The GRM rights can be bought or sold, like IP rights. Various regulations will determine how much we owe per gene.
People have been calling IT the "Information Revolution", but that has really only just begun. The singularity will (has) happen(ed) in meat before silicon.
This is activation in the "neurogenetic" circuit. We know that the soma thinks: "What Bodies Think About: Bioelectric Computation Outside the Nervous System" https://news.ycombinator.com/item?id=18736698 With a little practice you can establish two-way communication with this aspect of yourself ("neurosomatic" circuit) and engender e.g. accelerated healing, &c.
Now that we know that CRISPR-style genesplicing is possible, it seems likely that it could be taught as well. In other words, go into a trance and mutate yourself.
Our DNA already contains the coding for self-splicing, in fact it's littered with quiescent viruses in all degrees of viability. So we have all the biotechnology we need to practice self-modification of DNA now. Grok your cells! Go forth and mutate!
> Now that we know that CRISPR-style genesplicing is possible, it seems likely that it could be taught as well. In other words, go into a trance and mutate yourself.
It's not easy to unpack the train of thought there, and it would take a book (at least) to do it justice. Let me see if I can sum it up...
Your brain is a powerful feedback-based information processor. It's whole deal is to get your DNA into the future. Now it's learned about the existence of DNA. (Maybe from reading Dawkins.) And it's also learned about easy gene splicing with CRISPR. So as a bio-computer dedicated to self-replication, it has entered into a very strange loop.
I'm saying that this loop doesn't require any external hardware. You have a brain, you have cells, they are already connected, so you have your lab and Neural Network General (non-)AI already.
If you can convince your brain to try it (and this is where hypnosis comes into play) there is no reason to suspect that it wouldn't be able to figure out how to self-hack your own DNA. Just explain what to do and let 'er rip.
Is the implied attitude that if the rich get something first it shouldn’t exist at all? If gene therapy follows a progression like mobile phones, that would good for humanity. First it’s super expensive and only a few get them, but it becomes much cheaper within a few decades and eventually almost everyone can have one.