Certainly, a natural-born genius raised by wolves wouldn't make any great contributions to mathematics. I suspect that what gets missed in the nature/nurture debate that the two are in a complex feedback loop, with the result being the product not just of nature and nurture but how the two interacted. I would think even if we run out of low-hanging fruit in optimising our biology, correctly tailoring education to temperament (or vice versa if that's how the societies of the future prefer to approach it) could be another huge area of advancement.