... And yet the UI in the original Deus Ex (2000) supports not only tabbing and arrow keys, but Alt accelerator keys on every button as well, indicated with Windows-standard underlines. This includes the UI for interacting with in-game objects such as news kiosks. (I’ve just checked, and the table view supports sorting by clicking on a table header.)

I don’t expect it’s accessible to screen readers, but, well, it’s a 3D game.