I'm surprised this is buried by people suggesting Rails or Postgres or what have you. SQLAlchemy as good a SQL ORM as there is, and it isn't married to a framework, or a SQL backend.

If you like Python and want to use a SQL backend, SQLAlchemy is a good place to start.

SQLAlchemy is great, but you cannot say that it is simple :)

he says he loves the Django ORM. This is typically predictive of a poor response to SQLAlchemy's model :)

I've looked at SQL Alchemy and think it's pretty radical actually. I think that this evening/weekend I am actually going to begin doing this in flask+sqlalchemy. It was a strong contender from the beginning.

Here is my first flask app ever, https://github.com/whalesalad/arbesko-files

No authentication or session management or anything above basic request/response, but it was fun and serves it's purpose inside of Arbesko well.