I've looked at SQL Alchemy and think it's pretty radical actually. I think that this evening/weekend I am actually going to begin doing this in flask+sqlalchemy. It was a strong contender from the beginning.

Here is my first flask app ever, https://github.com/whalesalad/arbesko-files

No authentication or session management or anything above basic request/response, but it was fun and serves it's purpose inside of Arbesko well.